Drug metabolism and disposition: the biological fate of chemicals
Clopidogrel-indobufen conjugates as dual antiplatelet prodrugs with enhanced bioactivation and synchronized pharmacokinetic-pharmacodynamic profiles in rats.
Zhe Zhang, Dongchen Qin, Jiaxin Song, Huan Yang, Jingkai Gu, Yingjie Guo, Dong Sun
Published: 202510.1016/j.dmd.2025.100212
Abstract
A dual prodrug linking clopidogrel and indobufen-an established dual antiplatelet therapy combination-was designed to enhance the bioactivation of clopidogrel while enabling coordinated inhibition of the ADP and thromboxane A2 pathways of platelet ac…
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