Drug metabolism and disposition: the biological fate of chemicalsAnimalsHumansCytochrome P-450 CYP2C9MiceTolbutamide
Quantitative prediction of CYP2C9-mediated drug disposition using humanized mice.
Yuito Fujita, Haruka Tsutsui, Manabu Hirabayashi, Tomofumi Shimojo, Tatsuhiko Tachibana, Chie Emoto, Hidetoshi Shindoh, Kimio Terao, Taiji Miyake
Published: 202510.1016/j.dmd.2025.100185
Abstract
Drug clearance and drug-drug interactions (DDIs) are important in the pharmacokinetic assessment of investigational drugs, yet predicting in vivo fraction metabolized (fm) and DDI intensity remains challenging, particularly for low-clearance compound…
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