Drug metabolism and disposition: the biological fate of chemicalsCelecoxibPseudomonas aeruginosaAnimalsHumansCytochrome P-450 Enzyme System
The anti-inflammatory drug celecoxib is metabolized by Pseudomonas aeruginosa CYP107S1 in vitro and in vivo.
Sylvie E Kandel, Jed N Lampe
Published: 202510.1016/j.dmd.2025.100184
Abstract
The significance of the gut microbiome on drug metabolism has been demonstrated, yet much less is known about the pathobiome's potential impact on systemic drug metabolism outside of the β-lactam antibiotics, especially for bacterial species prone to…
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