Drug metabolism and disposition: the biological fate of chemicalsAnimalsGlycyrrhetinic AcidRatsStereoisomerismMale
Stereoisomerism at the 3-position of glycyrrhetinic acid affects pseudoaldosteronism-related toxicokinetics.
Ryota Sakoda, Taikei Saito, Asuka Hirasawa, Kan'ichiro Ishiuchi, Tomoya Yasujima, Hiroaki Yuasa, Toshiaki Makino
Published: 202510.1016/j.dmd.2025.100180
Abstract
Licorice-induced pseudoaldosteronism is attributed to the inhibition of 11β-hydroxysteroid dehydrogenase 2 in renal tubular cells by glycyrrhizic acid metabolites; however, the marked interindividual variability observed in toxic risk remains unclear…
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