Drug metabolism and disposition: the biological fate of chemicalsAnimalsPregnane X ReceptorRatsMaleLiver
Activation of pregnane X receptor-organic anion transporting polypeptide 1a/b /P-glycoprotein/multidrug resistance protein 2 axis mediates the accelerated blood and liver clearance of PEGylated liposomes.
Jianquan Pan, Cheng Zhang, Huiyu Lu, Xue Zhang, Huiya Deng, Yunna Chen, Lei Wang, Sheng Zhang, Fengling Wang, Weidong Chen
Published: 202510.1016/j.dmd.2025.100172
Abstract
Previous studies revealed that pregnane X receptor (PXR) was involved in the "accelerated blood clearance (ABC)" phenomenon induced by repeated injections of PEGylated liposomes, and observed the quickly reduced hepatic accumulation of the second dos…
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