Drug metabolism and disposition: the biological fate of chemicalsQuetiapine FumarateAldehyde OxidaseOxidation-ReductionHumansAntipsychotic Agents
Quetiapine competitively inhibits aldehyde oxidase-mediated reduction.
Hinata Ueda, Shuho Asano, Katsuya Narumi, Ryoichi Aoyagi, Keisuke Okamoto, Masaki Kobayashi
Published: 202510.1016/j.dmd.2025.100169
Abstract
Aldehyde oxidase (AOX) oxidizes nitrogen-containing heterocyclic drugs and reduces electron-deficient nitroaromatic drugs. The aim of this study was to elucidate the mode of inhibition of benzothiazepines such as quetiapine and clozapine, which are k…
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