Drug metabolism and disposition: the biological fate of chemicalsHumansHep G2 CellsBile Acids and SaltsAntifungal AgentsSteroid 12-alpha-Hydroxylase
Metabolic flux analysis of bile acid biosynthesis acidic pathway in HepG2 cells reveals CYP8B1 inhibition of azole antifungals.
Yixuan Wang, Tingting Yu, Xinjie Zhang, Yutong Wang, Lanlan Gui, Wushuang Zeng, Liang Huang, Ke Lan
Published: 202510.1016/j.dmd.2025.100168
Abstract
Sterol 12α-hydroxylase (CYP8B1) is a key regulator of bile acid (BA) homeostasis and an emerging therapeutic target for metabolic disorders. To address the challenge of cellular CYP8B1 inhibition characterization, this work developed a pharmacologica…
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