Drug metabolism and disposition: the biological fate of chemicalsHumansGlucuronidesFecesHydrolysisGlucuronidase
Hydrolysis of O-, N-, and N+-glucuronide metabolites in human feces.
Zhoupeng Zhang, April Chen, Niresh Hariparsad
Published: 202510.1016/j.dmd.2025.100163
Abstract
Glucuronides are phase 2 metabolites formed through the conjugation of glucuronic acid to the N or oxygen (O) atoms of drug molecules. The chemical and enzymatic stability of glucuronide metabolites under various conditions can aid in the processing…
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