Drug metabolism and disposition: the biological fate of chemicalsHumansAdenosine MonophosphateCarboxylesteraseAntiviral AgentsAlanine
Mechanistic insights into human carboxylesterase 2 (CES2) inhibition by the CES1 prodrug substrate remdesivir.
Abhinav Pentyala, Sylvie E Kandel, Jed N Lampe
Published: 202510.1016/j.dmd.2025.100158
Abstract
COVID-19 remains a significant health threat, particularly to people over the age of 65 with existing comorbidities like diabetes, hypertension, cancer, and viral infections. Despite expedited drug approvals, drug-drug interaction profiles for COVID-…
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