Cytokine & growth factor reviews
Spatiotemporal dynamic regulation of the CX3CL1-CX3CR1 axis: A double-edged sword in the tumor immune microenvironment and new strategies for precision therapy.
Jingtian Liang, Wenlong Zhu, Ruohan Pan, Shuli Wei, Shuangling Zhang, Zhe Zhang, Hongfei Tian
Published: 202610.1016/j.cytogfr.2026.01.006
Abstract
The CX3CL1-CX3CR1 signaling axis is a key yet functionally contradictory regulatory hub within the tumor immune microenvironment (TME), with its output shaped by spatiotemporal dynamics. This review seeks to address the core scientific question of ho…
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