Cytokine & growth factor reviewsNLR FamilyPyrin Domain-Containing 3 ProteinHumansSepsisInflammasomes
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies.
Yuhui Ma, Jialei Meng, Fangyuan Sun, Ming Lei
Published: 202510.1016/j.cytogfr.2025.09.006
Abstract
Sepsis is a life-threatening organ dysfunction triggered by a dysregulated host response to infection, with immune homeostasis imbalance at the core of its pathological mechanism. The NACHT, leucin-rich repeat (LRR) and pyrin domain (PYD)-containing…
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