CytokineInterleukin-7Dendritic CellsAnimalsT-LymphocytesCell Movement
IL-7 promotes naïve T cell motility to enable T cell scanning of dendritic cells in the LN.
Janie R Byrum, Kimberly A Morrissey, David J Torres, Sreenivasa Rao Oruganti, Judy L Cannon
Published: 202610.1016/j.cyto.2025.157105
Abstract
IL-7 is a key regulator of naïve T cell homeostasis including T cell development, survival, and proliferation. IL-7 is highly expressed in lymph nodes (LNs), and we investigated the potential for IL-7 to drive naïve T cell movement in LNs. We show th…
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