CytokineHumansCytokinesPurinesDrug RepositioningAzetidines
Drug repurposing for cytokine storm: baricitinib, ciclesonide, and acalabrutinib modulate cytokine release in a translational in vitro lymphoblastoid cell line model.
Luka Hiti, Tijana Markovič, Maša Kandušer, Irena Mlinarič-Raščan
Published: 202610.1016/j.cyto.2025.157083
Abstract
Cytokine storm, a life-threatening hyperinflammatory response seen in severe infections like COVID-19, autoimmune diseases, and certain therapies, remains difficult to treat due to limited approved therapeutics. To support preclinical drug developmen…
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