Current biology : CBAnimalsProtein Serine-Threonine KinasesProtein Phosphatase 1Drosophila ProteinsPhosphorylation
Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy.
Margarida Moura, João Barbosa, Inês Pinto, Nelson Leça, Sofia Cunha-Silva, Arianna Esposito Verza, Paulo D Pedroso, Sarah Lemaire, Joana Duro, Miguel Simoes-da-Silva, André Oliveira, Ricardo Reis, Jakob Nilsson, Claudio Sunkel, Andrea Musacchio
Published: 202510.1016/j.cub.2025.09.049
Abstract
Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains ill-defined. Here, we demonstrate in vitro and in Drosophila cells that the mitotic kinase Polo phosp…
Preview only. Read the full abstract at the source