Cancer treatment reviews
Exploring resistance to immune checkpoints inhibitors in mismatch repair-deficient or microsatellite-instable colorectal cancer.
Clara Salva de Torres, Evelyn Elias, Caterina Vaghi, Nadia Saoudi González, Ariadna García, Adriana Alcaraz, Marta Rodríguez-Castells, Iosune Baraibar, Javier Ros, Francesc Salvà, Josep Tabernero, Elena Élez, Enrique Sanz-Garcia
Published: 202610.1016/j.ctrv.2026.103089
Abstract
Colorectal cancer (CRC) with mismatch-repair deficiency (dMMR) or high microsatellite instability (MSI-H) represents a distinct molecular subtype highly sensitive to immune checkpoint inhibitors (ICIs). Landmark clinical trials have established ICIs…
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