Clinical and translational radiation oncology
Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC.
Steffen Löck, Lydia Koi, Kristin Gurtner, Fabian Lohaus, Max Kemper, Dominik Haim, Inge Tinhofer, Goda Kalinauskaite, Martin Stuschke, Maximilian Fleischmann, Claus Rödel, Anca-Ligia Grosu, Jürgen Debus, Claus Belka, Stephanie Combs
Published: 202610.1016/j.ctro.2025.101067
Abstract
Open AccessIn a previous preclinical trial on human HNSCC xenografts, 18 genes were predictive for adding cetuximab to fractionated radiotherapy. Here, we apply the corresponding 18-gene classifier to two HNSCC patient cohorts treated with combined radiochemotherapy (without cetuximab). We show that the classifier is related to EGFR expression and stratifies patients for loco-regional control (LRC) in both cohorts.