Cell reports methodsHumansOrganoidsBrain NeoplasmsMelanomaAntineoplastic Agents
Cortical organoid-derived models of the melanoma brain metastatic niche enable prioritization of cancer-targeting drugs.
Kim Krieg, Silvia Materna-Reichelt, Tobias Naber, Fatima-Zahra Rachad, Pia Kauven, Arjen Weller, Undine Haferkamp, Annika Wittich, Andrea Zaliani, Marcel S Woo, Mark Walkenhorst, Malte Siegmund, Jann Harberts, Robert Zierold, Robert Blick
Published: 202510.1016/j.crmeth.2025.101236
Abstract
Effective systemic therapies against brain metastases are severely limited. To understand and target vulnerabilities of human metastases in a brain niche context, we developed reproducible melanoma brain metastasis (MBM) models for metastasis-integra…
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