Computers in biology and medicineHumansReceptorsVasopressinDrug RepositioningAntidiuretic Hormone Receptor Antagonists
Early AI-driven repurposing study of existing drugs towards the vasopressin V2 receptor.
Daniela Trisciuzzi, Ines Angelini, Nicola Gambacorta, Mariangela Centrone, Fulvio Ciriaco, Lydia Siragusa, Annarita Di Mise, Marianna Ranieri, Giovanna Valenti, Nicoletta Guaragnella, Cosimo Damiano Altomare, Susanna Cotecchia, Grazia Tamma, Orazio Nicolotti
Published: 202610.1016/j.compbiomed.2025.111428
Abstract
The main goal of this study is the identification of existing drugs that could be repurposed as antagonists of the V2R, a GPCR controlling renal water balance and involved in abnormal cell proliferation, cancer, and renal cyst enlargement. Given its…
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