Patient-derived geometry-integrated multiphysics framework: Computational optimization of immunotherapeutic nanoparticle delivery via tumor microenvironment reprogramming in prostate cancer.

The immune checkpoint inhibitor (ICB) resistance of prostate cancer is due to its peculiar tumor microenvironment (TME), dense collagen stromal and disorganized vascularity, increased interstitial fluid pressure (IFP), blocked drugs and also immune c…

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