Computers in biology and medicineMycobacterium tuberculosisDNA GyraseTopoisomerase II InhibitorsMolecular Dynamics SimulationPlants
In silico identification of potential inhibitors of Mycobacterium tuberculosis DNA gyrase from Phytoconstituents of Indian medicinal plants.
Janmejaya Rout, Sayani Das, Sandip Kaledhonkar
Published: 202510.1016/j.compbiomed.2025.111343
Abstract
DNA gyrase, the sole type-II topoisomerase in Mycobacterium tuberculosis, plays a critical role in the bacteria's survival by catalyzing the DNA topology change and is considered a crucial drug target for tuberculosis treatment. The emergence of drug…
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