Computers in biology and medicineMolecular Docking SimulationProtein Kinase InhibitorsHumansMolecular Dynamics SimulationCyclin E
Identification of effective cyclin-dependent kinase 3/cyclin E inhibitors using multi-level computational screening and simulation.
Srutishree Sarma, Dikshita Dowerah, Shilpa Neog, Nishant Biswakarma, Priyanka Dutta, Gaurisankar Phukan, Ramesh Ch Deka
Published: 202510.1016/j.compbiomed.2025.111134
Abstract
INTRODUCTION: Cyclin-dependent kinase 3 (CDK3) plays a crucial role in regulating cell cycle progression through the G0/G1 and G1/S phases. Although extensively lowered in normal tissue, CDK3 is overexpressed in multiple cancers, making it a promisin…
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