Computational biology and chemistry
Tailored pyrrole-based imidazothiazole scaffolds: Synthetic elaboration, enzyme kinetic profiling and DFT-guided molecular docking toward Antidiabetic therapeutics.
Zanib Fiaz, Shoaib Khan, Tayyiaba Iqbal, Wajid Rehman, Anila Fareed, Rafaqat Hussain, Kayumov Khasan Yusuf Ogli, Merajuddin Khan, Mohammed Rafi Shaik
Published: 202610.1016/j.compbiolchem.2026.108920
Abstract
The current research study highlights the successful biological evaluation of novel imidazo-thiadiazole based pyrrole derivatives, with the aim of targeting diabetes mellitus through alpha-amylase and alpha-glucosidase inhibition. These compounds exh…
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