Computational biology and chemistryHumansCarcinomaHepatocellularLiver NeoplasmsLiver Cirrhosis
Integrative metabolomic and transcriptomic profiling reveals distinct metabolic signatures of hepatocellular carcinoma arising from cirrhosis.
Junxi Ni, Qiuming Song, Daoli Liu, Yongwei Zhang, Yun Sun
Published: 202610.1016/j.compbiolchem.2025.108863
Abstract
BACKGROUND: Substantial metabolic reprogramming accompanies the transition from cirrhosis to hepatocellular carcinoma (HCC), yet the metabolomic profile of cirrhotic liver tissue containing HCC remains insufficiently defined. METHODS: Metabolomic dat…
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