Computational biology and chemistryHumansValosin Containing ProteinSpinocerebellar AtaxiasTranscriptomeMolecular Docking Simulation
Valosin-Containing Protein as a therapeutic target in CAG repeat-driven Spinocerebellar ataxias: Integrative transcriptomic and computational insights.
Surbhi Singh, Deepika Joshi, Janki Makani, Suchitra Singh, Janhavi Yadav, Shraddha Chaurasiya, Chandmayee Mohanty, Anand Kumar, Royana Singh
Published: 202610.1016/j.compbiolchem.2025.108838
Abstract
Spinocerebellar ataxias (SCAs) are progressive neurodegenerative disorders caused by abnormal CAG repeat expansions in genes such as ATXN1, ATXN2, and ATXN3, with no effective therapeutic options currently available. To identify key molecular drivers…
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