Computational biology and chemistryThiazolesGlycoside Hydrolase Inhibitorsalpha-Glucosidasesalpha-AmylasesHypoglycemic Agents
Synthesis and computational studies on novel thiazine-thiazole hybrid analogues as dual α-amylase and α-glucosidase inhibitors for combating diabetes mellitus.
Wajid Rehman, Yousaf Khan, Thoraya A Farghaly, Hina Sarfraz, Komal Arooj, Mahrukh Naseem
Published: 202610.1016/j.compbiolchem.2025.108786
Abstract
Thiazole-linked thiazine scaffolds represent an emerging class of heterocycles with potential therapeutic relevance in metabolic disorders. Here, we report the design, synthesis, and structural characterization of ten novel derivatives (1-10), confir…
Preview only. Read the full abstract at the source