Computational biology and chemistryHumansTriazolesGlioblastomaAntineoplastic AgentsDrug Screening Assays
1,2,4-triazole incorporated into polyheterocyclic scaffolds as anti-glioblastoma agents: Biological evaluation and molecular modeling studies.
Mikołaj Biegański, Marius Bidon, Monika Karpińska, Radosław Rola, Joanna Matysiak, Andrzej Niewiadomy, Monika Szeliga
Published: 202610.1016/j.compbiolchem.2025.108771
Abstract
Glioblastoma (GBM) remains the most lethal brain tumor with limited treatment options and poor prognosis. The design of new anti-GBM drug candidates is of utmost need. Here we assessed the activity of 1,2,4-triazolo[3,4-a]phthalazine and 1,2,4-triazo…
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