Computational biology and chemistryArginineHydrogen-Ion ConcentrationAdministrationOralInsulin
Design and computational characterization of arginine-functionalized ZIF-8 as a pH-responsive oral insulin carrier.
Ali Muneer Abdulrahman, Dina Hadi Abdullah Alaqebe, Zainab Abdullah Kareem, Eman Mohammed Jasim, Mohammed Mahmood Abdullah, Alaa Hamid Faisal, Mustafa M Kadhim
Published: 202610.1016/j.compbiolchem.2025.108711
Abstract
This study presents a computational framework to evaluate arginine-modified ZIF-8 (ZIF-8@Arg) as a potential oral insulin delivery system. In contrast to unmodified metal-organic frameworks, the inclusion of arginine residues introduces guanidinium g…
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