Naringenin nanosuspensions embedded glycyrrhizin-based hydrogel ameliorates cholestatic liver injury in mice by inhibiting oxidative stress and HMGB1-mediated inflammation.

Naringenin (NAR) possesses remarkable hepatoprotective potential. However, its extremely low aqueous solubility and oral bioavailability greatly constrain its therapeutic efficacy. To overcome these limitations, we developed a novel oral nanodelivery…

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