Colloids and surfaces. B, Biointerfaces
Lysosome-targeted ROS-responsive graphene oxide-based drug delivery system to overcome tumor DOX resistance.
Fengzhu Yang, Jintao Deng, Xinyu Yu, Wenhao Fu, Wenlong Sun, Zhengbao Xu, Xinhua Song, Chao Wang, Qingqing Du, Meng Wang
Published: 202610.1016/j.colsurfb.2026.115434
Abstract
The lysosomes of drug-resistant tumor cells transport doxorubicin (DOX) and its nanocarriers into lysosomes through a sequestration mechanism, making it difficult for DOX to reach the therapeutic concentration. In this study, a nanodrug delivery syst…
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