Computer methods and programs in biomedicineDrug RepositioningHumansPrecision MedicineSystems BiologyNeoplasms
Drug repurposing through pathway perturbation dynamics: A systems biology approach for precision oncology.
Xianbin Li, Wuxiang Ruan, Guoan Lu, Dingcheng Ban, Luming Tian, Binbin Wang, Tao Liu, Guodao Zhang, Chunping Wang, Jie Lin
Published: 202610.1016/j.cmpb.2025.109177
Abstract
BACKGROUND AND OBJECTIVE: Drug repurposing offers a cost-efficient strategy to discover new therapeutic applications for approved drugs. While current computational strategies prioritize candidates by targeting disease-related pathways, they often fa…
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