Cell metabolism
Ferroplasticity drives social isolation-induced anxiety via a ventral hippocampal iron-α-synuclein axis.
Zhuo Wang, Sifan Yang, Tianrong Huang, Jinhui Zhao, Shuangyi Tan, Yuhan Zhang, Tianming Lü, Pingming Qiu, Junxia Min, Fudi Wang
Published: 202610.1016/j.cmet.2025.12.022
Abstract
Social isolation is a major environmental driver of anxiety disorders, yet its neurobiological underpinnings remain elusive. We report here that social isolation triggers "ferroplasticity"-a novel form of experience-dependent synaptic remodeling-in v…
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