Cell metabolismAnimalsHumansMutationObesityReceptor
Benign form of monogenic obesity conferred by the melanocortin 4 receptor.
Anke Hinney, Triinu Peters, Luisa Sophie Rajcsanyi
Published: 202610.1016/j.cmet.2025.12.006
Abstract
Mutations that impair the function of the melanocortin 4 receptor (MC4R) cause severe obesity in both heterozygous and homozygous carriers. However, recent findings indicate that individuals with this form of monogenic obesity may be unexpectedly pro…
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