Cell metabolismHepatic Stellate CellsAnimalsHumansMiceDisease Models
Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH.
Fiorella Di Pastena, Jaya Gautam, James S V Lally, Russta Fayyazi, Estelle Grasset, Dipankar Bhattacharya, Gio Fidelito, Elham Ahmadi, Logan K Townsend, Battsetseg Batchuluun, Daniela Carmen Oniciu, Spencer Heaton, Roger S Newton, Theodoros Tsakiridis, Evangelia E Tsakiridis
Published: 202610.1016/j.cmet.2025.11.015
Abstract
Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by steatosis, inflammation, and fibrosis driven by hepatic stellate cell (HSC) activation. Acetyl-CoA is central to de novo lipogenesis (DNL) and cholesterol synthesis and is ge…
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