Cell metabolismReceptorsG-Protein-CoupledAnimalsEnteroendocrine CellsHumans
Gut enteroendocrine cell activation using a combination of GPR119 and GPR40 agonists results in synergistic hormone secretion in mice and humans.
Iyassu K Sebhat, Monika J M Murphy, Shuqin Zheng, Robert J Lovelett, Maja Engelstoft, Daniel Kosinski, Xiaodong Yang, Victoria Dunn, John Whang, Maximilian G Lombardo, Adrian Heilbut, Giuseppe Terracina, Nicole Nicholas, Molly Leitner, Matthew J Consolati
Published: 202610.1016/j.cmet.2025.11.001
Abstract
A leading hypothesis for the effectiveness of bariatric surgery for weight loss is supraphysiologic activation of gut enteroendocrine cells (EECs), which results in elevated postprandial levels of satiety hormones, including glucagon-like peptide-1 (…
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