Cell metabolismAnimalsProlactin-Releasing HormoneMiceFatty AcidsOxidation-Reduction
Analog of prolactin-releasing peptide reduces body weight primarily through sustained fatty acid oxidation rather than hypophagia.
Claire H Feetham, Sam Groom, Linu M John, Berit Ostergaard Christoffersen, Valeria Collabolletta, David Lyons, Antony Adamson, Sofia Lundh, Marina Kjærgaard Gerstenberg, Mads Tang-Christensen, Kilian W Conde-Frieboes, Anna Secher, Ann Maria Kruse Hansen, Simon M Luckman
Published: 202610.1016/j.cmet.2025.10.021
Abstract
Prolactin-releasing peptide and its cognate receptor, G protein-coupled receptor (GPR)10, are important in the physiological regulation of body weight in both rodents and humans. Here, we describe a modified peptide, NN501, with agonist properties at…
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