Cell metabolismGlutamineHomeostasisAnimalsSleepMice
Intestinal clock shapes sleep-wake cycle via sustaining glutamine homeostasis.
Lianxia Guo, Yifei Xiao, Zanjin Li, Yuwei Huang, Haobin Cen, Zicong Wu, Hongbo Wang, Xinyu Liu, Zhehan Yang, Caifeng Zhao, Tingying Hao, Hui Chen, Meng Jin, Danyi Lu, Min Chen
Published: 202510.1016/j.cmet.2025.10.010
Abstract
The intestinal clock plays a role in transmitting feeding signals and generating circadian events, but how this clock system may time homeostatic processes related to sleep-wake regulation is unknown. Our functional dissections of the circadian clock…
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