Cell metabolismAnimalsMicePhenotypeGenetic VariationCholesterol
Leveraging genetic and phenotypic variation to discover metabolite-protein interactions.
Gregory S Ducker, Jared Rutter
Published: 202510.1016/j.cmet.2025.10.008
Abstract
How metabolites regulate protein function is still poorly understood. Leveraging the power of genetic variation, Xiao et al. built a global protein-metabolite covariation dataset to reveal novel protein-metabolite regulations in mouse that led to the…
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