Cell metabolismAMP-Activated Protein KinasesAnimalsHumansMiceAlzheimer Disease
AMPKα2 signals amino acid insufficiency to inhibit protein synthesis.
Yunzi Mao, Mei Cui, Yanfeng Jiang, Haowen Yu, Meng Wang, Gang Li, Haihui Zhang, Cheng Zhao, Yanxin Shen, Yupeng Hu, Yanpeng An, Yan Lin, Yiyuan Yuan, Pengcheng Lin, Xingdong Chen
Published: 202610.1016/j.cmet.2025.09.004
Abstract
The functional difference between the two catalytic subunits, α1 and α2, of AMP-activated protein kinase (AMPK) complexes remains elusive. Herein, we report that AMPKα2 specifically transduces amino acid insufficiency signals to protein synthesis. Lo…
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