Clinical therapeuticsHumansOmeprazoleFemaleAdultFood-Drug Interactions
Phase 1 Study Evaluating the Effect of Food and Omeprazole-Induced Gastric pH Change on the Pharmacokinetics and Safety of Imlunestrant in Healthy Females.
Amita Datta-Mannan, Elaine Shanks, Eunice Yuen, Yingying Guo, Xuejing Aimee Wang
Published: 202610.1016/j.clinthera.2025.10.007
Abstract
PURPOSE: To assess the effect of low-fat food intake and the effect of a gastric acid reducing agent (omeprazole) on imlunestrant pharmacokinetics (PK), safety, and tolerability. METHODS: A phase 1, open-label cohort study (NCT04840888) in healthy ad…
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