Clinical immunology (Orlando, Fla.)AnimalsSjogren's SyndromeEndoplasmic Reticulum StressAutophagyTOR Serine-Threonine Kinases
Regulation of Ro52/SSA autoantigen by endoplasmic reticulum stress and ERK1/2-mTOR-autophagy signaling pathway in primary Sjögren disease.
Qianwen Tian, Qi Xi, Qiaolin Zhang, Yun Chen, Yunxin Zhang, Fuxue Kuang, Lejie Sun, Song Peng, Huaxun Wu
Published: 202610.1016/j.clim.2025.110655
Abstract
Primary Sjögren disease (pSS) is an autoimmune disease characterized primarily by predominant lymphocytic infiltration of the exocrine glands. While the etiopathogenesis of pSS remains unclear, current therapeutic strategies lack efficacy. In human s…
Preview only. Read the full abstract at the source