Clinical immunology (Orlando, Fla.)HumansMultiple SclerosisCyclooxygenase 2AnimalsDinoprostone
The dual role of the COX-2/PGE2 Axis in multiple sclerosis: From pathogenesis to pharmacological inhibition.
Ahmed Salem Al-Dhahi, Hayder M Al-Kuraishy, Nawar R Hussain, Mohamed N Fawzy, Mubarak Alruwaili, Huda J Waheed, Ali I Al-Gareeb, Ali K Albuhadily, Gaber El-Saber Batiha
Published: 202610.1016/j.clim.2025.110643
Abstract
Multiple sclerosis (MS) is a chronic neuroinflammatory and demyelinating disease of the central nervous system (CNS). The cyclooxygenase-2/prostaglandin E2 (COX-2/PGE2) axis plays a complex, dual role in its pathogenesis. Although its upregulation ty…
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