The Canadian journal of cardiology
Activation of Endothelial TRPV4 Exacerbates Myocardial Ischemia-Reperfusion Injury via Vascular Integrity Impairment.
Miaomiao Zhang, Yan Zou, Hongyun Ruan, Yingyu Chen, Zixuan Li, Yan Liu, Yimei Du, Bing Han
Published: 202510.1016/j.cjca.2025.11.007
Abstract
BACKGROUND: Activation of transient receptor potential vanilloid 4 (TRPV4) exacerbates myocardial ischemia-reperfusion (IR) injury and is highly expressed in vascular endothelial cells. The role of TRPV4 in cardiac endothelial cells (CECs) during IR…
Preview only. Read the full abstract at the source