Journal of chromatography. A
Structure-guided design of a minimal epitope tag and nanobody affinity system.
Jiayi Tan, Limin Zhao, Mu Li, Kanglong Yang, Yue Li, Yuqing Ding, Heng Liu, Houjun Xia, Chongyuan Wang, Jiawei Li
Published: 202610.1016/j.chroma.2026.466675
Abstract
The isolation of recombinant proteins commonly relies on affinity-based methods. Nevertheless, widely used tags and solid supports are frequently constrained by insufficient specificity, harsh elution requirements, and cost inefficiency. Here, we dev…
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