Journal of chromatography. AHumansDependovirusChromatographyIon ExchangeGenetic Therapy
Integrating the affinity and anion-exchange purification of AAV8: how the selective enrichment of full capsids at the affinity capture step enhances the downstream processing of gene therapies.
Shriarjun Shastry, Arianna Minzoni, Morgan R Hurst, Crystal Collazo, Eduardo Barbieri, Wenning Chu, Joseph Taris, Patrick Gilbert, Christopher Major, Michael Daniele, Stefano Menegatti
Published: 202610.1016/j.chroma.2025.466557
Abstract
Adeno-associated virus (AAV) vectors are revolutionizing gene therapy with remarkable therapeutic potential. Yet, their clinical translation is limited by inadequate biomanufacturing technologies that compromise product quality and accessibility. Add…
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