Journal of chromatography. AMetabolomicsChromatographyLiquidHydrophobic and Hydrophilic InteractionsCalibration
Absolute quantification of polar metabolites using matrix-free calibration curves and post-column infusion of standards in HILIC-MS based metabolomics.
Mengle Zhu, Lieke Lamont, Pascal Maas, Amy C Harms, Marian Beekman, P Eline Slagboom, Anne-Charlotte Dubbelman, Thomas Hankemeier
Published: 202510.1016/j.chroma.2025.466507
Abstract
Polar metabolites play essential roles in inflammation, immune regulation, and metabolism, and have emerged as important biomarkers in clinical research. However, accurate absolute quantification of these metabolites in complex biological matrices us…
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