Highly sensitive monitoring of genotoxic impurity 2-nitrobenzaldehyde in pharmaceutical formulations via hyper-crosslinked polymer-based solid-phase microextraction.

2-Nitrobenzaldehyde (2-NBA), a key intermediate in the synthesis of nifedipine, is a potential genotoxic impurity that poses significant health risks even at trace levels. This study develops a novel solid-phase microextraction (SPME) method using a…

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