Journal of chromatography. AAerosolsChromatographyHigh Pressure LiquidDrug ContaminationLimit of Detection
Multi-attribute characterization of pharmaceutical materials by HPLC coupled with charged aerosol detection.
Frank Hrovat, Mara Zimmer, Melody Fu, Jason Gruenhagen, Kelly Zhang, Juan Bian, Jessica Lin
Published: 202510.1016/j.chroma.2025.466424
Abstract
((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol (2S-FHPM) is a common building block in drug molecules, yet its small size and lack of chromophore pose a significant analytical challenge. To address this, we have developed a high perfor…
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