Cell host & microbeAnimalsMiceHumansGastrointestinal MicrobiomeSteroids
Gut bacteria metabolize natural and synthetic steroid hormones via the reductive OsrABC pathway.
Christian Jacoby, Kaylie Scorza, Lia Ecker, Paola Nol Bernardino, Alexander S Little, Mary McMillin, Ramanujam Ramaswamy, Anitha Sundararajan, Ashley M Sidebottom, Huaiying Lin, Keith Dufault-Thompson, Brantley Hall, Xiaofang Jiang, Samuel H Light
Published: 202510.1016/j.chom.2025.09.014
Abstract
Steroid hormone metabolism by the gut microbiome affects host physiology, however, the underlying microbial pathways remain incompletely understood. Here, we isolate a gut bacterial species, which we designate Clostridium steroidoreducens, that reduc…
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