Cell chemical biology
Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.
Garrett L Lindsey, Thomas K Hockley, Alejandro Villa Gomez, Andrew C Marshall, William R Brothers, Colin T Finney, Jacob Gross, Archa H Fox, Gene W Yeo, Bruno Melillo, Charles S Bond, Benjamin F Cravatt
Published: 202610.1016/j.chembiol.2025.12.010
Abstract
RNA-binding proteins (RBPs) play important roles in mRNA transcription, processing, and translation. Chemical tools are lacking for RBPs, which has hindered efforts to perturb and understand RBP function in cells. We previously described a chloroacet…
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