Cell chemical biologyReceptorsOpioidmuAnimalsNeurons
Targeted inhibition of mu-opioid receptors in neuronal subpopulations by membrane-tethered Naloxo-DART antagonists.
J Sanchez, A Bonifazi, S Groom, M O Sambrook, G A Camacho-Hernandez, E J Kuijer, S Karimi, K U Therese, M Hauge Pedersen, C Rauffenbart, M Canals, A H Newman, C P Bailey, J A Javitch, J R Lane
Published: 202510.1016/j.chembiol.2025.11.002
Abstract
Opioid receptors are expressed in virtually all neural loci contributing to the experience of pain. Due to this widespread expression, the contribution of specific cell types to the analgesic properties and deleterious side effects of opioids remains…
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